Just wrote you about aspirin and found this -for me – new information!
I asked a hematologist about a test for aspirin sensitivity but it seems that he was not aware of this test? This was a couple of years ago, maybe the test did not exist yet.
- Diagnostic Profile
A New Immunologic Diagnostic Test for Monitoring Aspirin Effect
• Atherothrombosis, the major cause of acute coronary syndromes, remains the world’s leading cause of morbidity and mortality. Platelets are central to the process of atherothrombosis and, therefore, antiplatelet therapies have been widely advocated in managing this disorder.
• Low-dose aspirin (acetylsalicylic acid) is commonly prescribed as an antiplatelet therapy for secondary prevention of serious ischemic events. However, recent reports suggest that not all patients respond to low-dose aspirin to the same degree. Conservative estimates of aspirin nonresponsiveness (also known as ‘aspirin resistance’) range from 5 to 25%, depending on the testing platform and clinical status of the tested patient population.
• The prevalence of aspirin resistance suggests a need for a test to monitor aspirin response in the individual patient. Such a test would allow for individualized treatment rather than treatment of the disease on a population basis.
• Historical methods to assess the effect of aspirin on platelet function involve ex vivo platelet aggregation techniques that are not conducive to mass screening of individuals.
• Aspirin exerts its antiplatelet effect through inhibition of the platelet cyclooxygenase (COX) pathway and subsequent reduction in thromboxane A2 (TxA2) production. Assessment of the adequacy of COX-1 pathway inhibition by aspirin can be performed by measuring levels of 11-dehydrothromboxane B2 (11dhTxB2), a stable metabolite of TxA2.
• AspirinWorks® is an FDA cleared competitive immunoassay in microplate format that measures levels of 11dhTxB2 in urine specimens. This test may be used by physicians to monitor aspirin effect and assist in optimizing antiplatelet therapy in individual patients.
I will try to look into it [and you arr invited to do the same] I wrote in the past that it is likely far better to take soluble aspirin and not any of the COATED tablets on the market! [micropirim,tevapitin etc][Please DON’T stop if you take any of these]