One group received no additional treatment, the second took 100 mg a day of aspirin and a third
received the aspirin plus the combination of extracts of French maritime pine bark (150 mg/day) and Centella asiatica [Gotu kola] (450 mg/day).
At the end of the three years, more than 20% of patients in the standard management and the aspirin group had progressed to more severe and extensive atherosclerotic plaque.
Among patients treated with aspirin + pine bark + Centella, only 5.3% of patients experienced plaque progression.