אלופורינול – תרופה מאוד שימושית אך לא ללא סכנות חמורות במיוחד – נדמה שאינה מגנה על הכליות בחולים עם חומצת שתן גבוהה. אז אם אתה משתמש באלופורינול למטרה זו, דון בזה עם הרופא שלך.

בכל מקרה של חומצת שתן גבוהה אכלו מדי יום הרבה דובדבנים!

Allopurinol -a very useful medicine but not without very serious dangers sometimes- seems not to protect the kidneys in patients with high uric acid.

So if you are using allopurinol for this purpose then discuss it with your doctor.

In any case of high uric acid eat daily plenty of cherries!

“But despite this very nice reduction in uric acid, we could not see any effect on GFR,” Doria says.

He and his colleagues will continue to follow participants through their medical records and through national databases that track people who eventually progress to dialysis or kidney transplants.

Researchers at Joslin and other institutions continue to examine other potential routes to guard against kidney disease among people with type 1 diabetes.

Despite its disappointing conclusion, “PERL was a textbook example of using epidemiology to find treatment targets, and then designing a study to translate those findings and try to find a new intervention,” Doria says. “In this case, it didn’t work. But this is exactly why we do epidemiological studies, and how our scientific understanding advances.”

Story Source:

Materials provided by Joslin Diabetes Center. Note: Content may be edited for style and length.

Journal Reference:

  1. Alessandro Doria, Andrzej T. Galecki, Cathie Spino, Rodica Pop-Busui, David Z. Cherney, Ildiko Lingvay, Afshin Parsa, Peter Rossing, Ronald J. Sigal, Maryam Afkarian, Ronnie Aronson, M. Luiza Caramori, Jill P. Crandall, Ian H. de Boer, Thomas G. Elliott, Allison B. Goldfine, J. Sonya Haw, Irl B. Hirsch, Amy B. Karger, David M. Maahs, Janet B. McGill, Mark E. Molitch, Bruce A. Perkins, Sarit Polsky, Marlon Pragnell, William N. Robiner, Sylvia E. Rosas, Peter Senior, Katherine R. Tuttle, Guillermo E. Umpierrez, Amisha Wallia, Ruth S. Weinstock, Chunyi Wu, Michael Mauer. Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes. New England Journal of Medicine, 2020; 382 (26): 2493 DOI: 10.1056/NEJMoa1916624