In a clever world we could make -B”H-peace with Iran maybe by appreciating their tremendous work in plant medicine [ Phytotherapy] and spending most weapon money to promote their research and giving them a leading world-role -combined with honor-in their research in this field. Utopia? I don’t think so. We have a problem in the Western world……all our achievement are “superior” above other nations, and we often became extremely “atheistic” because of the new egel ha-zahav: science used in a wrong way.

Epub 2017 May 8.

Milad Iranshahy 1Behjat Javadi 2Mehrdad Iranshahi 1Seyedeh Pardis Jahanbakhsh 3Saman Mahyari 3Faezeh Vahdati Hassani 4Gholamreza Karimi 5Affiliations collapse

Affiliations

  • 1Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 2Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 3Pharmaceutical Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 4Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 5Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: KarimiG@mums.ac.ir.

Abstract

Ethnopharmacological relevance: Portulaca oleracea L. is a widespread medicinal plant that is used not only as an edible plant, but also as a traditional medicine for alleviating a wide spectrum of diseases. It is a well-known plant in the European Traditional Medicine. PA is mentioned by Dioscorides (40-90 CE), with the name of “andrachne”.

Aim of the review: In this study, we provide detailed information on botany, traditional uses, phytochemistry, pharmacological uses, pharmacokinetics and safety of P. oleracea.

Materials and methods: An extensive search on electronic databases including PubMed, Web of Science, Google Scholar, ScienceDirect, Scopus, conference papers, local herbal encyclopedias, articles, books (in English, French, Arabic, Persian, etc.) and also a number of unpublished handwritten manuscripts was done to find articles have been published between 1956 and 2015 on pharmacology and phytochemistry of P. oleracea.

Results: P. oleracea has been addressed in De Materia Medica as an astringent, and a remedy for headaches, inflammation of the eyes and other organs, burning of the stomach, erysipelas, disorders of the bladder, numbness of the teeth, excessive sexual desire, burning fevers, worms, dysentery, hemorrhoids, eruptions of blood, and bites. Phytochemical investigations revealed that this plant a wide range of secondary metabolites including alkaloids, terpenoids, flavonoids and organic acids. The most important pharmacological activities are renoprotective activities and effects on metabolism. P. oleracea could successfully decrease blood glucose and lipid profile of patients with metabolic syndrome. The safety of P. oleracea has been reported in many clinical trials.

Conclusion: Modern pharmacological studies have now proven many traditional uses of P. oleracea, including anti-hyperglycemic and anti-hyperlipidemic, renoprotective and hepatoprotective effects. In addition, in many clinical trials P. oleracea showed no adverse effects and constipation was reported as the most frequent adverse effect.

Keywords: Anti-hyperglycemic; Anti-hyperlipidemic; Ethnopharmacology; Hepatoprotective; Portulaca oleracea L.; Renoprotective.