ONE remark can “kill” a patient! Don’t trust any X-ray or lab result if it does not totally fit with the clinical picture

One remarAn electron microscope image shows a chaotic variety of cellular structure inside someone’s brain. The dye used to stain the cells means everything has a pink or purple hue.

Hello Nature readers,
Today, we discover a genetic mutation that protected a man from early-onset Alzheimer’s disease, ponder the ethics of human DNA bycatch and find out what life after the International Space Station will look like.
The brain of a person with Alzheimer’s disease shows an amyloid plaque and tau fibres (dark pink lines) under the electron microscope. (Thomas Deerink/NCIR/SPL)
How one man’s mutation delays Alzheimer’sA rare genetic mutation seems to have protected a man from early-onset Alzheimer’s disease. Like many of the 6,000 members of his extended family, the man carried a mutation that leads people to develop Alzheimer’s in their forties or earlier. But he also had a second mutation in a gene coding for a protein called reelin. The man’s brain scans looked like that of a person with severe dementia, with high levels of amyloid plaques — yet he had only mild cognitive impairment in his late 60s. The study challenges the theory that the plaques are the primary cause of Alzheimer’s.Nature | 6 min read
Reference: Nature Medicine paper