Many put a few seeds in their coffee [especially the Arab population]

Conclusion: Cardamomum extract administered immediately after stress might help to prevent the formation of anxiety-like behavior in the animals. Further studies are suggested to clarify the exact mechanism involved [PTSD]

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Effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of PTSDyaser masoumi-Ardakani1, Khadijeh Esmaeilpour2 , Hamid Najafipour3, Amin Mirzaei4, Gholamreza Sepehri21-Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran2- Neuroscience Research Center, Institute of neuropharmacology, Kerman Univerity of Medical Sciences, Kerman, Iran3-Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran4-Department of Biology, Fars Science and Research Branch, Islamic Azad University, Shiraz, IranIntroduction: PTSD is a debilitating psychiatric condition which develops in 6-8 % of general population in their life time. Though there are standard pharmacological treatments available for PTSD, their side effects limits their usage. Cardamomum is known as an anxiolytic agent in traditional medicine. The objective of the current study was to evaluate the effect of cardamomum extract on anxiety-like behavior in a rat model of PTSD.Methods: Adult male wistar rats were used for the current study. Methanolic extract of cardamomum was prepared in different dosages (200, 400 and 800 mg/kg). Rats underwent single prolonged stress (SPS) or sham and received either saline or different dosages of cardamomum extract immediately after stress sessions. Open field test and elevated plus maze were used to evaluate locomotion and anxiety-like behavior in the animals. p<0.05 was considered statistically significant.Results: Cardamom extract (400 mg/kg) administered immediately after stress increased locomotion and decreased anxiety-like behavior in the animals of SPS group.Conclusion: Cardamomum extract administered immediately after stress might help to prevent the formation of anxiety-like behavior in the animals. Further studies are suggested to clarify the exact mechanism involved.Keywords: PTSD; Cardamomum; Anxiety-like behavior; Rat