The article is not clear to me, the conclusion :yes.
Conclusion: In this study, the formulation has a large impact on reducing lead poisoning.
Effect of aqueous extract of Melissa officinalis and jujube fruit on weight and
biochemical factors of lead-poisoned kidney in mice
Mahmoud Ghasemi1, Roksana Sheikhi1, Mahnaz Rashidi1, Mohammad Alimoradi2
1-Hospital doctor Mohammed kermanshahi, Kermanshah University of Medical Sciences, Kermanshah, Iran
2-Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Introduction: Lead can enter the body through a variety of organisms and organs of the body,
including the kidney are affected. This study effects formulations on biochemical factors kidney
and weight studied in mice will lead poisoning.
Methods: The experimental study on 40 adult male mice with an average weight of 35-30 g and
then randomly divided into four equal groups Compatible courses, Include: (1) Control group:
saline recipient. (2) Sham group1: received lead acetate for 7 days and after 25 days of normal
diet. (3) Sham group2: received formulations for 25 days with a dose of 200 mg/kg. (4)
intervention group: which received a solution of lead acetate in drinking water at a dose
(ppm1000) for 7 days and 25 days post -dose formulation 200 mg/kg, The results of the
statistical program (SPSS version 16), and The T-test were analyzed.
Results: Weighing animals in sham1 group than in all groups studied, a significant increase
(p<0/05) and in sham2 group was significantly decrease than the control group, But there was no
significant difference between the intervention group and the control group. The numerical value
of urea and creatinine in shame1 group than in all groups showed a significant increase, but in
the intervention and sham2 group compared with the control group showed no significant
difference.
Conclusion: In this study, the formulation has a large impact on reducing lead poisoning.
Keywords: Lead; Melissa officinalis and Ziziphus jujube extract; Mice; Kidney