We identified in this study a large number of plants which
were traditionally used in European Renaissance as antiepileptics.
A majority of these plants have not been investigated pharmacologically with respect to potential antiepileptic activity. For some
of the plants discussed in more detail available pharmacological
evidence is, in part, in support of, in part in cotrast to the
traditional use. Only 5% of the plant species presented in
Table 1 have shown ’’in vitro and/or in vivo pharmacological data
somehow related to the indication epilepsy. A systematic screening of the uninvestigated plants for activity in disease-relevant
targets (e.g., GABAA and NMDA receptors) would be of interest.
We have characterized a broad spectrum of GABAA receptor
modulators from herbal drugs traditionally used in TCM as
sedative, anxiolytics and antiepileptics (Yang et al., 2011; Zaugg
et al., 2011a,b,c; Kim et al., 2012). Also, our previous study of
malaria remedies from Renaissance herbals resulted in a focused
screen of these plants and the identification of active constituents
(Adams et al., 2010, 2011b; Hata et al., 2011; Julianti et al., 2011;
S´lusarczyk et al., 2011; Zimmermann et al., 2012a). Hence, we
anticipate that potentially useful molecules could be discovered
from some of the plants listed in this publication