Taken independently, ACE inhibitors
or ARBs are reasonably safe and
quite effective for controlling
high blood pressure. When these
categories are combined, however,
there can be serious complications.
A review of 33 randomized
controlled trials in (BMJ, Jan 28,
2013) comparing treatment with one
single blood pressure medication to
“dual blockade” with both an ARB
and an ACE inhibitor together
revealed some scary results.
The combination therapy led to an
increased risk of a potentially
life-threatening condition called
hyperkalemia (excessive potassium
levels). Too much potassium can
lead to cardiac arrest. Other
adverse reactions associated with
dual therapy included hypotension
(very low blood pressure) and
kidney failure