Patients who for some reason are taking methotrexate would be wise to take at least a capsule of milk thistle or even more,  to protect against liver damage caused by methotrexate .
California Gold Nutrition, Milk Thistle Extract, EuroHerbs, European Quality, 175​ 2x per day


Also, highly recommended in these cases is Triphala. This significantly restored intestinal brush border membranes in methotrexate-damaged rats. 

Planetary Herbals, Triphala, GI Tract Wellness, 1,000 mg, 180 Tablets​  2x per day one with food.