Will Andrographis be useful?
Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner
In the present study, our results reveal that AG inhibits cell viability and induces autophagic cell death in OS cells by suppressing the PI3K/Akt/mTOR pathway and enhancing the JNK pathway. AG-induced autophagy also inhibits the invasion and metastasis of OS cells. These results suggest that AG may represent a promising novel targeted agent in the prevention and treatment of OS. Further investigation of AG in mouse models will contribute to the understanding of its in vivo activity against malignant cells.
A. paniculata has been extensively used as traditional medicine in India, China and Southeast Asia. The aerial parts possess most of the medicinal properties and are used to treat snakebites, insect stings, fever, sore throat, cough and stomachache.
Various good supplements of Andrographis