From the American Botanical Council [ABC]

Psilocin is a serotonin 5-HT2A receptor agonist and can activate cortical regions of the brain. Psilocybin produces a global increase in cerebral metabolic rate of glucose and marked alterations in brain network connectivity. Psilocybin also causes regional differences in brain perfusion. Psilocybin can decrease activity in the Default Mode Network including the medial prefrontal cortex, an area that is activated in people with depression. “Psychedelics do not simply make the brain more random, but rather after the normal organization is disrupted, strong, topologically long-range functional connections emerge that are not present in the normal state.” Studies demonstrate that there may be long-term changes in brain functioning after a single administration of psilocybin.

The author proposes that psilocybin is poised to make a significant impact on psychiatric treatment but acknowledges that clinical data need to be validated by larger studies.

—Heather S. Oliff, PhD