My remarks:

A kind of oil [GLA] which maybe easily “lacking” if you are on prescription medicines or have certain diseases.

It is important to buy a safe brand, not extracted by solvents

2 good brands [hexane, solvent free] https://www.iherb.com/tr/cb?pcodes=AMH-03231qty1sid0_NFS-02365qty1sid0&v=2&rcode=RKK609

I always have warned patients not to take this without asking when suffering from epilepsy.

Below I send now an article which claims that this is probably not true and that it CAN be taken in cases of epilepsy. [still ask]

From the website of Dr Weil

You have likely seen it on the shelves of your drug or health food store, but do you know what evening primrose oil can do for you? This natural source of gamma-linolenic acid (GLA) is a versatile oil that comes from the tiny seeds of a wildflower, Oenothera biennis L., native to North America.

Very hard to come by in the diet, GLA has been studied for its natural anti-inflammatory activity, and it appears to have none of the side effects of the over-the-counter anti-inflammatory drugs. I frequently suggest evening primrose oil to support skin health, as well as optimal health of hair and nails. Do not expect immediate results; it takes six to eight weeks to see changes after adding GLA to the diet. When purchasing, choose evening primrose oil that is cold-pressed and extracted without the use of solvents.

. 2007 Aug;77(2):101-3. doi: 10.1016/j.plefa.2007.07.003. Epub 2007 Aug 30.

The safety of evening primrose oil in epilepsy

B K Puri 1Affiliations expand

Abstract

The concern that evening primrose oil might cause epilepsy or seizures, or reduce the threshold for seizures, originated from two papers published in the early 1980s. These original reports are re-examined, and the association of evening primrose oil with seizures is shown to be spurious. Not only are linoleic acid and gamma-linolenic acid safe in epilepsy, with prolonged oral administration of linoleic acid and alpha-linolenic acid (in a 4:1 mixture) protecting rats from having seizures in four different epilepsy models, but the evening primrose oil-derived omega-6 fatty acid arachidonic acid inhibits sodium ion currents and synaptic transmission, while the evening primrose oil-derived eicosanoid prostaglandin E(1) appears to have anticonvulsant activity. In light of these findings, it is suggested that formularies should now remove seizures or epilepsy as a side-effect of evening primrose oil, and should remove a history of seizures or epilepsy as a contraindication to taking evening primrose oil.