Yinma Jiedu Granules are composed of Licorice (Glycyrrhiza uralensis Fisch.), honeysuckle (Lonicera japonica Thunb.), portulaca (Portulaca oleracea L.), rhubarb (Rheum palmatum L.), and plantain (Plantago asiatica L.)

In summary, we screened the active components of TCM Yinma Jiedu Granules and explored and predicted their pharmacological mechanisms for the therapy of COVID-19 through network pharmacology. Network pharmacology and the molecular docking method confirm the “multicomponent, multipathway, multitarget mechanisms” for the therapeutic actions of Yinma Jiedu Granules in the treatment of COVID-19. The present work may provide valuable evidence for further clinical application of Yinma Jiedu Granules for treating COVID-19 and may lay a good theoretical foundation for further experimental verification and facilitate the widespread application of the TCM in treating the serious and life-threatening pulmonary infection caused by SARS-CoV-2