האם ניתן לתת יחד מיני תוספים שונים?

לעיתים ניתן לראות תוצאות בלתי צפויות משילוב של תוספים טבעיים. אלו די נדירים, אך ייתכן שיהיה חכם להתייעץ עם מומחה אם אתה מתכוון להשתמש בתוספים לזמן רב. אל תפחד: במקרה הגרוע, הם כמעט תמיד יותר בטוחים מתרופות מסורתיות [אם ניתן לעשות בלעדיהן]. להלן דוגמה של זרעי ענבים וויטמין C יחד, שנראה כי עלולים להגביר לחץ דם. אך כמות ה-GSE נראית לי יוצאת דופן גבוהה ואני לא יודע למה כמות זו הוזמנה [1000 מ”ג] [הם כתבו פוליפנולים ואני מניח שהם היו בצורת מחוטבי ענבים]. אני לעולם לא נותן יותר מ-150 מ”ג GSE [או לעיתים נדירות 300 מ”ג], לכן זה הפרש קטן, אני חושב.

J Hypertens. 2005 Feb;23(2):427-34

Can all kinds of supplements being given together?

Sometimes we can see unexpected results from a combination of natural supplements.These are rare but it may be wise to consult an expert if you are going to use supplements for a longer time.Don’t get scared: in the worst case they are virtually always safer than conventional medicines [if you can do without these]
Below aan example of grape seed and vitamin C together which seems to possibly raise blood pressure.But the amount of GSE seems to me extraordinary high and I don’t know why this amount was used [1000 mg][they wrote polyphenols and is suppose this was in the form of grape seed extract.] I never give more than 150 mg GSE[or rarely 300 mg], so that is a bit of a difference, I would think.

J Hypertens. 2005 Feb;23(2):427-34.The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial.Ward NC1, Hodgson JM, Croft KD, Burke V, Beilin LJ, Puddey IB.Author information1School of Medicine and Pharmacology, University of Western Australia and West Australian Institute for Medical Research (WAIMR), Perth, Australia. nward@cyllene.uwa.edu.auAbstractBACKGROUND:There is growing evidence that oxidative stress contributes to the pathogenesis of hypertension and endothelial dysfunction. Thus, dietary antioxidants may beneficially influence blood pressure (BP) and endothelial function by reducing oxidative stress.OBJECTIVE:To determine if vitamin C and polyphenols, alone or in combination, can lower BP, improve endothelial function and reduce oxidative stress in hypertensive individuals.DESIGN:A total of 69 treated hypertensive individuals with a mean 24-h ambulatory systolic blood pressure > or = 125 mmHg participated in a randomized, double-blind, placebo-controlled, factorial trial. Following a 3-week washout, participants received 500 mg/day vitamin C, 1000 mg/day grape-seed polyphenols, both vitamin C and polyphenols, or neither for 6 weeks. At baseline and post-intervention, 24-h ambulatory BP, ultrasound-assessed endothelium-dependent and -independent vasodilation of the brachial artery, and markers of oxidative damage, (plasma and urinary F2-isoprostanes, oxidized low-density lipoproteins and plasma tocopherols), were measured.RESULTS:A significant interaction between grape-seed and vitamin C treatments for effects on BP was observed. Vitamin C alone reduced systolic BP versus placebo (-1.8 +/- 0.8 mmHg, P = 0.03), while polyphenols did not (-1.3 +/- 0.8 mmHg, P = 0.12). However, treatment with the combination of vitamin C and polyphenols increased systolic BP (4.8 +/- 0.9 mmHg versus placebo; 6.6 +/- 0.8 mmHg versus vitamin C; 6.1 +/- 0.9 mmHg versus polyphenols mmHg, each P < 0.0001) and diastolic BP (2.7 +/- 0.6 mmHg, P < 0.0001 versus placebo; 1.5 +/- 0.6 mmHg, P = 0.016 versus vitamin C; 3.2 +/- 0.7 mmHg, P < 0.0001 versus polyphenols). Endothelium-dependent and -independent vasodilation, and markers of oxidative damage were not significantly altered.CONCLUSION:Although the mechanism remains to be elucidated, these results suggest caution for hypertensive subjects taking supplements containing combinations of vitamin C and polyphenols.