tiredness,fatigue, cfs עייפןת

Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: A randomised, double-blind, controlled pilot study

J.H. Cho^a, C.K. Cho^a, J.W. Shin^a, J.Y. Son^a, W. Kang^b and C.G. Son^a, , 

Available online 23 January 2009. 

 

Summary

Objectives

To investigate the anti-fatigue effects of Myelophil, an extract of a mix of Astragali Radix and Salviae Radix, which has been used to treat patients with chronic fatigue.

Subjects and design

A randomised, double-blind, controlled clinical trial was performed with 36 adults who complained of chronic fatigue. The subjects were divided among a control group and low- and high-dose groups (3 or 6 g of oral Myelophil per day, respectively) and were monitored for 4 weeks. Fatigue severity was subjectively characterised, and the expression of 42 cytokines was evaluated using an antibody array.

Results

Myelophil administration (3 g per day) significantly decreased the fatigue severity score compared with the control (p < 0.05). No changes were noted in cytokine expression.

Conclusions

Myelophil appears to have a pharmacological effect against fatigue, suggesting the clinical relevance of the traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza.

Keywords: Chronic fatigue; Astragalus membranaceus; Salvia miltiorrhiza; Herbal medicine

Article Outline

Introduction

Subjects and methods

Subjects

Composition of Myelophil and the placebo

Study protocol

Assessment based on the Chalder fatigue severity scale and a visual analogue scale

Cytokine antibody array

Statistical analysis

Results

Change in fatigue severity as determined by NRS

Change in fatigue severity as determined by VAS

Serum cytokine profiles

Discussion

Acknowledgements

References

 

 

 

corresponding author. Tel.: +82 42 470 9481; fax: +82 4

prptiredness prpcfs prpfatigue