MARA VE-MATSAV RUACH [RAMBAM] OUR BILE AND OUR MOOD………LOW BILIRUBIN. For a long time in the history of medicine, the 4 honours have played a major role in medicine. Greek physician Hippocrates (ca. 460 BCE–370 BCE) is often credited with developing the theory of the four humors—blood, yellow bile, black bile, and phlegm—and their influence on … Continue reading Low levels of bilirubin linked to depression.